Goals

EcoFAB is an initiative that aims at building model laboratory ecosystems across worldwide research laboratories to study environmental microbiomes for investigation of soil carbon cycling and low input sustainable crop production.  Through this initiative, a lab scale device or fabricated ecosystem has been developed to study soil-plant-microbe interactions in a reproducible and controllable system. 

 

Despite the investment and promise of plant-associated microbiome research, typical approaches are focused on examination of individual isolates or field studies of complex native communities.  There exists a need for a reproducible, controllable and observable lab scale model that accurately represents field conditions.  Our solution to this is the EcoFAB with a focus on four key objectives:

  1. Observability: to measure biogeochemical processes with unprecedented resolution on nested scales.  This would enable a theoretical modeling science known as mesoscale systems biology.
  2. Reproducibility: to recapitulate the system and its dynamics at will. Because this is a biological system, there will be variation, but this variation must be manageable as it is in model organism developmental biology. A reproducible system is required for testing predictions and evaluating models.
  3. Controllability: to make defined, targeted perturbations or manipulations to the cohort of species, their spatiotemporal community structures or dynamics, and their genetic complements – all in biochemical and geophysical context. The ability to manipulate our system is a prerequisite for hypothesis testing.
  4. Ecosimilarity: to assess the extent to which our bench-top model reproduces key behavior observed in open-field, real-world systems. Ultimately, the lessons we learn must be transferable to extant ecologies to enable interventions promoting ecoremediation and a healthier planet.